The final Practice session of the weekend saw Marc Marquez top the timesheets in the dry conditions.
Marc Marquez continues to lead at the Circuit of the Americas in the dry conditions on Saturday morning. The eight-time World Champion was fastest on Friday evening and has carried on where he left off.
Alex Marquez was behind his brother in second place, but he was 0.4 seconds slower than the GP25.
Maverick Vinales launched himself into third place in the dying moments of the session. The Red Bull KTM Tech3 rider was half a second behind Marc Marquez and looked quick in the dry.
Honda continues to show good form in America as Joan Mir ended the session in fourth place on the RC213V.
Francesco Bagnaia ended the final Practice session in fifth place and had his best session of the weekend.
Luca Marini was just behind his fellow VR46 Academy rider as he ended the Saturday morning session in sixth place.
The top Yamaha in the dry conditions was Fabio Quartararo, who ended Free Practice Two in seventh on the Monster Energy Yamaha.
The Pertamina Enduro VR46 Racing Team riders ended the session in eighth and ninth place. Fabio di Giannantonio was in eighth, and Franco Morbidelli was in ninth.
Red Bull KTM Factory Racing rider, Pedro Acosta, completed the top ten.
MotoGP America, Full Free Practice Two Results:
| 2025 American MotoGP | Circuit of the Americas | Free Practice Two Results | Round 3 of 22 | |||||
| Pos | Name | Nat. | Team | Bike | Times |
| 1 | Marc Marquez | ESP | Ducati Lenovo Team | Ducati GP25 | 2:02.113 |
| 2 | Alex Marquez | ESP | BK8 Gresini Racing MotoGP | Ducati GP24 | 2:02.553 |
| 3 | Maverick Vinales | ESP | Red Bull KTM Tech3 | KTM RC16 | 2:02.656 |
| 4 | Joan Mir | ESP | Honda HRC Castrol | Honda RC213V | 2:02.690 |
| 5 | Pecco Bagnaia | ITA | Ducati Lenovo Team | Ducati GP25 | 2:02.860 |
| 6 | Luca Marini | ITA | Honda HRC Castrol | Honda RC213V | 2:02.888 |
| 7 | Fabio Quartararo | FRA | Monster Energy Yamaha | Yamaha M1 | 2:02.945 |
| 8 | Fabio di Giannantonio | ITA | Pertamina Enduro VR46 Racing Team | Ducati GP25 | 2:02.965 |
| 9 | Franco Morbidelli | ITA | Pertamina Enduro VR46 Racing Team | Ducati GP24 | 2:02.988 |
| 10 | Pedro Acosta | ESP | Red Bull KTM Factory Racing | KTM RC16 | 2:03.147 |
| 11 | Marco Bezzecchi | ITA | Aprilia Racing | Aprilia RS-GP | 2:03.200 |
| 12 | Fermin Aldeguer | ESP | BK8 Gresini Racing MotoGP | Ducati GP24 | 2:03.208 |
| 13 | Jack Miller | AUS | Prima Pramac Racing | Yamaha M1 | 2:03.446 |
| 14 | Johann Zarco | FRA | LCR Honda Castrol | Honda RC213V | 2:03.463 |
| 15 | Raul Fernandez | ESP | Trackhouse Racing | Aprilia RS-GP | 2:03.562 |
| 16 | Enea Bastianini | ITA | Red Bull KTM Tech3 | KTM RC16 | 2:03.650 |
| 16 | Ai Ogura | JPN | Trackhouse Racing | Aprilia RS-GP | 2:03.679 |
| 18 | Brad Binder | RSA | Red Bull KTM Factory Racing | KTM RC16 | 2:03.713 |
| 19 | Alex Rins | ESP | Monster Energy Yamaha | Yamaha M1 | 2:04.153 |
| 20 | Augusto Fernandez | ESP | Prima Pramac Racing | Yamaha M1 | 2:04.989 |
| 21 | Somkiat Chantra | THA | LCR Honda IDEMITSU | Honda RC213V | 2:05.392 |
| 22 | Lorenzo Savadori | ITA | Aprilia Racing | Aprilia RS-GP | 2:05.917 |
