At the end of the opening day of Practice at the San Marino Grand Prix, Marc Marquez topped the timesheets.
Marc Marquez started the weekend in fifth place in Free Practice One, but in the afternoon session, he was in control as he topped the Practice session on the factory Ducati.
After ending up in eighth place in Free Practice One, Marco Bezzecchi made his way up the order in the afternoon Practice session as he finished in second place and was 0.147 seconds behind Marquez.
Franco Morbidelli topped Free Practice One on the Pertamina Enduro VR46 Racing Team Ducati, but slipped back to third in the afternoon session.
After a terrible Friday last week at the Catalan Grand Prix, Francesco Bagnaia had a positive start to his weekend at Misano as he ended the opening day in fourth place.
Rounding out the top five was the BK8 Gresini Racing MotoGP rider, Alex Marquez, who ended the day in fifth place on the Ducati GP24.
The factory Honda HRC Castrol squad had a positive opening day at the San Marino Grand Prix as both riders secured a Q2 spot with a sixth place for Joan Mir and a seventh place for Luca Marini.
Jorge Martin was able to secure himself a spot in Q2 on Saturday as he ended the Friday afternoon Practice session in eighth place on the Aprilia Racing RS-GP.
The top KTM in the Friday afternoon session was the Red Bull KTM Factory Racing rider, Pedro Acosta, who was the only KTM rider to secure an automatic Q2 spot.
Completing the top ten was the Pertamina Enduro Vr46 Racing Team rider, Fabio di Giannantonio.
MotoGP San Marino, Full Practice Results:
| 2025 San Marino MotoGP | Misano World Circuit Marco Simoncelli | Practice Results | Round 16 of 22 | |||||
| Pos | Name | Nat. | Team | Bike | Times |
| 1 | Marc Marquez | ESP | Ducati Lenovo Team | Ducati GP25 | 1:30.480 |
| 2 | Marco Bezzecchi | ITA | Aprilia Racing | Aprilia RS-GP | 1:30.627 |
| 3 | Franco Morbidelli | ITA | Pertamina Enduro VR46 Racing Team | Ducati GP24 | 1:30.673 |
| 4 | Pecco Bagnaia | ITA | Ducati Lenovo Team | Ducati GP25 | 1:30.710 |
| 5 | Alex Marquez | ESP | BK8 Gresini Racing MotoGP | Ducati GP24 | 1:30.752 |
| 6 | Joan Mir | ESP | Honda HRC Castrol | Honda RC213V | 1:30.819 |
| 7 | Luca Marini | ITA | Honda HRC Castrol | Honda RC213V | 1:30.848 |
| 8 | Jorge Martin | ESP | Aprilia Racing | Aprilia RS-GP | 1:30.857 |
| 9 | Pedro Acosta | ESP | Red Bull KTM Factory Racing | KTM RC16 | 1:30.889 |
| 10 | Fabio di Giannantonio | ITA | Pertamina Enduro VR46 Racing Team | Ducati GP25 | 1:30.915 |
| 11 | Johann Zarco | FRA | LCR Honda Castrol | Honda RC213V | 1:31.068 |
| 12 | Fabio Quartararo | FRA | Monster Energy Yamaha | Yamaha M1 | 1:31.090 |
| 13 | Brad Binder | RSA | Red Bull KTM Factory Racing | KTM RC16 | 1:31.166 |
| 14 | Maverick Vinales | ESP | Red Bull KTM Tech3 | KTM RC16 | 1:31.249 |
| 15 | Raul Fernandez | ESP | Trackhouse Racing | Aprilia RS-GP | 1:31.487 |
| 16 | Jack Miller | AUS | Prima Pramac Racing | Yamaha M1 | 1:31.500 |
| 17 | Enea Bastianini | ITA | Red Bull KTM Tech3 | KTM RC16 | 1:31.572 |
| 18 | Fermin Aldeguer | ESP | BK8 Gresini Racing MotoGP | Ducati GP24 | 1:31.616 |
| 19 | Augusto Fernandez | ESP | Yamaha Factory Racing Team | Yamaha M1 | 1:31.678 |
| 20 | Alex Rins | ESP | Monster Energy Yamaha | Yamaha M1 | 1:31.682 |
| 21 | Ai Ogura | JPN | Trackhouse Racing | Aprilia RS-GP | 1:31.688 |
| 22 | Miguel Oliveira | POR | Prima Pramac Racing | Yamaha M1 | 1:32.369 |
| 23 | Somkiat Chantra | THA | LCR Honda IDEMITSU | Honda RC213V | 1:32.516 |
